The Colonials trailed by one point to Duquesne at halftime, but the Dukes responded with a 42-point second half to take the win.
Senior guard Mei-Lyn Bautista has missed the last two contests due to a possible concussion.
The men’s and women’s indoor and outdoor track and field teams each set a new program record in the A-10 outing.
Massachusetts entered the game as the best three-point shooting team in the Atlantic 10, but was held to 8.7 percent shooting from deep by the Colonials.
Head coach Terry Weir said the Colonials have a chance to cause upsets on the track at the A-10 Championship meet this season.
The Colonials are in the midst of a four-game losing streak, averaging just 42.5 points per game in the last four contests after averaging 61.3 points per game in the three games prior.
Brianna Barry was the head volleyball coach at Southeastern Oklahoma State University from 2014 to 2018.
George Mason sophomore guard Nicole Cardano-Hillary led the floor with a career-high 37 points while no other Patriot recorded more than seven points.
The Colonials will have their work cut out for them to keep up with the Patriots’ offense on the team’s home court.
Before its match against La Salle Sunday, men’s tennis did not see action since Nov. 9 at the Navy Gold Invitational.